Exosomes

Both are per-natal (young) cell lines, but Amniotic fluid has a significantly different protein profile than XoGlo and it lacks key proteins like TGF-B3, which is an important modulator of inflammation and immune function. Also, the exosomes in amniotic fluid are derived from maternal epithelial cells not the mesenchymal stem cell origin so they do not have as many growth factors as the MSC’s.

Bone-marrow derived exosomes originate primarily from hematopoietic stem cells (HSC’s) rather than mesenchymal stem cells, which are the source of the exosomes in XoGlo. These HSCs are progenitor cells of the blood cell lineages, not the connective tissue lineages, and so their exosomal cargo is much different than that of MSC exosomes. The very low numbers of MSC’s that are present in adult bone marrow also differ significantly from peri natal MSC's in their exosome production.

After being frozen for storage, the number of viable cells in these stem cell products is very low. Also, any viable allogeneic cells only survive for a few very short period time, during which they act by releasing exosomes, meaning that the effects of these products are dependent on the growth factors and a low concentration of exosomes present. XoGlo has billions of peri-natal MSC exosomes, and these exosomes remain viable after frozen storage. Also, unlike XoGlo, the growth factors in these products are not protected from degradation by a liposomal membrane.

1. Exosomes are administered as an IV infusion for systemic illness, Neuro-regeneration, degenerative diseases, and autoimmune disorders. Exosomes can also be administered directly into areas around soft tissue injury.
2. Exosomes are used on the skin for many Aesthetic skin procedures by microneedling as a topical serum.
3. 1 day prior to IV Exosome treatment we administer a NAD+ boost to optimize the cell function.

Although rare, you may have local pain, rash, nausea, or mild fever. Some patients may have Beandryl prior to Exosomes for sensitive patients. Usually, patients do not feel anything after IV infusion.  Above symptoms will be resolved in 1-3 days.

In order to obtain optimal response from Exosome therapy, the recommendations are as following:

• No NSAIDS before and after Exosome therapy
• No over strenuous activity for the first 24-48 hours
• Resume cardio workouts 2 weeks after treatment

• Both are safe procedures, but stem cells cannot be used for IV infusion without proper process.  
• Exosomes derived from stem cells are not proliferative, no chance to become tumor like stem cells do.
• Viral reaction and body rejection are extremely unlikely, Exosomes are too small molecular, they are not cells or tissue, could not cause immune response but immune modulation.

No, as they are NOT embryonic stem cells. Exosomes do not multiply. Exosomes transfer valuable biological signals to the recipient’s tissues and facilitate the normalization of various pathological processes.

In some case a follow-up treatment may be advised. There is no sustainable data about standard dosing and the treatment is as individual as the response. Some patients may need a single application, while others need multiple doses or a small booster therapy. In some cases, therapy may start with a small initial dose which is increased over time.

Exosomes triggers a bi-phasic response, immediate reaction in 24 hours, then messenger RNAs that inserted into target cells to help reprogram the cells which usually takes 6-8 weeks. The continued effect may continue for months after infusion or injection. Thus, a patient who received Exosome therapy should wait at least 8 weeks before deciding if another treatment is needed.